BM-1244

SKU: orb1693363

Description

BM-1244 is a potent small molecule inhibitor of the anti-apoptotic proteins Bcl-xL (Ki = 134 nM) and Bcl-2 (Ki = 450 nM). It effectively eliminates senescent cells in vitro, demonstrating an EC50 of 5 nM in senescent fibroblast assays, making it a useful research tool for studying apoptosis and senescence.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1619923-32-8
• MW: 1159.78
• Formula: C₅₄H₅₉ClF₄N₆O₈S₄
• SMILES: CC(C)n1c(C)c(c(c1-c1ccc(Cl)cc1)-c1cc(F)cc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(CC3)C(O)=O)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)cc1)S(C)(=O)=O
• Target: Others,PARP,Bcl-2 Family,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

90279478