BLT-1

SKU: orb1308549

Description

BLT-1 is a potent and selective small molecule inhibitor of the scavenger receptor BI (SR-BI). It is a valuable research tool for investigating SR-BI's role in cholesterol metabolism and viral entry in both cellular and animal models.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 321673-30-7
• MW: 241.4
• Purity: 98.30% (May vary between batches)
• Formula: C₁₂H₂₃N₃S
• SMILES: CCCCCCC1CCC\C1=N\NC(N)=S
• Target: HCV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.29 mM);DMSO:38.67 mg/mL (160.19 mM)

Bioactivity

• In Vitro:
  BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC50=0.057 μM) and liposomes (IC50=0.098 μM) . BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

chelator, copper, Block lipid transport 1, Block lipid transport1, Block lipid transport-1, BLT 1, BLT1, BLT-1, inhibit, lipoproteins, lipids, neutrophil, Inhibitor, Hepatitis C virus, HDL, HCV, HCVProtease, HCV Protease, high-density, thiosemicarbazone, recruitment, pro-inflammatory, SR-BI, scavenger, Transfer

Compound Identifiers

PubChem CID

5719399