Blasticidin S HCl

SKU: orb1819230

Description

Blasticidin S HCl is a broad-spectrum, natural product antibiotic that inhibits protein synthesis. It is widely used in molecular biology for in vitro and in vivo selection of genetically modified cells and in research fields such as microbiology and cell biology.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 3513-03-9
• MW: 458.9
• Purity: >98%
• Formula: C₁₇H₂₆N₈O₅·HCl
• SMILES: Cl.CN(CC[C@H](N)CC(=O)N[C@@H]1C=C[C@@H](O[C@@H]1C(O)=O)n1ccc(N)nc1=O)C(N)=N
• Target: Antibiotic
• Solubility: Soluble in Water (50 mg/ml)

Bioactivity

• Target IC50:
  MRSA:59.7 ± 7.8 μg/mL|K. pneumoniae:42.3 ± 3.5 μg/mL|E. faecalis:26.3 ± 13 μg/mL|VRE:58.0 ± 9.4 μg/mL|S. aureus:33.2 ± 0.8 μg/mL|P.aeruginosa:61.0 ± 6.0 μg/mL|A. baumannii:104 ± 25 μg/mL
• In Vitro:
  METHODS: Yeast cells Schizosaccharomyces pombe were treated with Blasticidin S HCl (0.1-60 μg/mL) for 18 h, and the absorbance was measured to detect the inhibition of cell growth. RESULTS: Blasticidin S HCl inhibits the growth of Schizosaccharomyces pombe cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

protein synthesis, Antibiotic

Compound Identifiers

PubChem CID

155859124