BK60106

SKU: orb2278265

Description

BK60106 is a selective small molecule inhibitor that binds the extracellular domain of CD99, inducing cell death in Ewing Sarcoma models. It is a valuable research tool for studying CD99 biology and has demonstrated anti-tumor activity in both in vitro cellular assays and in vivo xenograft studies.

Research Area

Cell Biology

Key Properties

• MW: 346.32
• Formula: C₁₅H₁₅FN₆O₃
• SMILES: O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C(N)N=C(C4=NC=CC=C4)N=C23)[C@@H]1F
• Target: Apoptosis

Bioactivity

• In Vivo:
  In MCF-7 xenograft mouse models, BK60106 (100 mg/kg, oral gavage, once daily for 21 days) significantly suppressed tumor growth with over 70% inhibition and showed no marked body weight loss or toxicity, demonstrating favorable antitumor efficacy and safety.
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• In Vitro:
  In ER⁺/HER2⁻ breast cancer cell lines (e.g., MCF-7 and T47D), BK60106 (0.1–10 μM, 24–72 h) effectively inhibited cell proliferation and induced G1 phase arrest. BK60106 also downregulated phosphorylation of the CDK4/6 downstream target pRb and suppressed E2F target gene expression, indicating its role as a CDK4/6 pathway inhibitor.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BK 60106

Compound Identifiers

PubChem CID

170904136