BIX-01294 trihydrochloride

SKU: orb1306973

Description

BIX-01294 trihydrochloride is a cell-permeable, potent, and selective inhibitor of the G9a histone methyltransferase, exhibiting an IC50 of 2.7 μM in biochemical assays. It is widely used in epigenetics research to probe the role of histone H3 lysine 9 methylation in gene silencing, cellular differentiation, and has been applied in both cellular and animal studies.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1392399-03-9
• MW: 600.02
• Purity: 99.95% (May vary between batches)
• Formula: C₂₈H₃₈N₆O₂·3HCl
• SMILES: Cl.Cl.Cl.COc1cc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC)N1CCCN(C)CC1
• Target: Autophagy,Histone Methyltransferase
• Solubility: DMSO:260 mg/mL (433.32 mM);H2O:60 mg/mL (100 mM)

Bioactivity

• Target IC50:
  G9a:2.7 μM
• In Vivo:
  In wild-type embryonic stem (ES) cells, mouse embryonic fibroblasts, and HeLa cells, BIX-01294 (4.1 μM) reduces the levels of H3K9me2. BIX-01294 can specifically inhibit G9a (IC50=1.7 μM) and GLP (IC50=38 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cdkn1a, Autophagy, BIX 01294, BIX01294, BIX-01294, H3K9me2, H3K9me3, G9a, Gadd45a, HistoneMethyltransferase, Histone Methyltransferase, p53, MLKL, p21, SUV39H1(H320R), recurrent, PRMT1

Compound Identifiers

PubChem CID

46945860