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Ro 31-8425

SKU: orb1309922

Description

Bisindolylmaleimide X hydrochloride is a potent, selective inhibitor of protein kinase C (PKC) and also antagonizes CDK2 with an IC50 of 200 nM. This cell-permeable compound is widely used in biochemical and cellular research to investigate PKC and CDK2 signaling pathways in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Images & Validation

Key Properties

CAS Number145317-11-9
MW460.96
Purity>98%
FormulaC26H24N4O2 · HCl
SMILESCl.Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12
TargetKinase
SolubilitySoluble in DMSO (up to 10 mg/ml)

Bioactivity

Target IC50
CDK2:200 nM|PKC:200 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BIM X; Bisindolylmaleimide X

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Key Properties

No computed properties available.

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Protocol Information

Ro 31-8425 (orb1309922)

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1 mg
$ 170.00
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