Bisindolylmaleimide VIII acetate

SKU: orb1309924

Description

Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent, selective inhibitor of protein kinase C (PKC), with IC50 values ranging from 53 to 213 nM across multiple PKC isoforms. It is widely used in biochemical research to investigate PKC-mediated signaling pathways in cellular and animal models of cancer, inflammation, and neurological disorders.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 138516-31-1
• MW: 458.51
• Purity: 99.00% (May vary between batches)
• Formula: C₂₆H₂₆N₄O₄
• SMILES: CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
• Target: PKC,Apoptosis
• Solubility: DMSO:55 mg/mL (119.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.36 mM)

Bioactivity

• Target IC50:
  PKCβ2:163 nM|PKC:158 nM(Rat Brain)|PKCγ:213 nM|PKCα:53 nM|PKCε:175 nM|PKCβ1:195 nM
• In Vivo:
  Bisindolylmaleimide VIII acetate (100 μg; i.p.; every other day for three doses) results in nearly complete tumor regression combined toTRA-8. The alone treatment with Bisindolylmaleimide VIII acetate does not induce significant tumor regression .
• In Vitro:
  Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. Bisindolylmaleimide VIII acetate (5 μM; 8, 12 hours) dramatically increases TRA-8-induced cell death in time-dependent and TRA-8 dose-dependent manners. Bisindolylmaleimide VIII acetate (5 μM; 6 hours) significantly decreases procaspase-8 at 4 h and completely disappears at 6 h after the combined treatment with TRA-8 .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell-mediated, diseases, Bisindolylmaleimide VIII, Bisindolylmaleimide VIII acetate, Bisindolylmaleimide VIII Acetate, Bis VIII, Bis VIII acetate, Bis VIII Acetate, autoimmune, Apoptosis, Inhibitor, kinase, inhibit, Fas, Ro 31-7549, Ro 31-7549 acetate, Ro 31-7549 Acetate, Protein kinase C, protein, PKC, PKCα, PKC-α, PKCβ2, PKCβ1, PKC-βI, PKC-βII, PKCε, PKC-ε, PKCγ, PKC-γ, Rat Brain PKC

Compound Identifiers

PubChem CID

9868770