Bisindolylmaleimide IV

SKU: orb1299618

Description

Bisindolylmaleimide IV is a potent and cell-permeable inhibitor of protein kinase C (PKC), exhibiting an IC50 range of 0.10 to 0.55 µM. This small molecule is widely used in biochemical and cellular research to investigate PKC-mediated signaling pathways in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 119139-23-0
• MW: 327.34
• Purity: 98.83% (May vary between batches)
• Formula: C₂₀H₁₃N₃O₂
• SMILES: O=C1NC(=O)C(C2=CNC3=CC=CC=C23)=C1C1=CNC2=CC=CC=C12
• Target: PKC,Virus Protease
• Solubility: DMSO:3.28 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.05 mM)

Bioactivity

• Target IC50:
  HCMV:0.2 μM|PKC:0.10 - 0.55 µM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

selective, PKC, Protein kinase C, disease, discriminative, DMSO, Cytomegalovirus, CMV, Bisindolylmaleimide IV, Arcyriarubin A, Inhibitor, human, inhibit

Compound Identifiers

PubChem CID

2399