Bisdemethoxycurcumin

SKU: orb1222461

Description

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.

Key Properties

• CAS Number: 24939-16-0
• MW: 308.33
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₆O₄
• SMILES: Oc2ccc(/C=C/C(=O)CC(=O)/C=C/c1ccc(O)cc1)cc2
• Target: p300|Wnt/β-catenin
• Solubility: In Vitro: DMSO : 66.67 mg/mL (216.23 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Curcumin III, Bisdemethoxycurcumin

Quick Database Links

Gene Symbol

p300|Wnt/β-catenin