Bisabolangelone

SKU: orb1297442

Description

Bisabolangelone is a bioactive small molecule with demonstrated anti-tumor, anti-inflammatory, antimicrobial, and antioxidant properties. Its mechanism involves suppressing dendritic cell activity through the inhibition of MAPK and NF-κB signaling pathways, making it a useful research tool in immunology and oncology for in vitro studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 30557-81-4
• MW: 248.32
• Purity: 99.65% (May vary between batches)
• Formula: C₁₅H₂₀O₃
• SMILES: [H][C@]12CC(C)=CC(=O)[C@@]1([H])[C@@](C)(O)\C(O2)=C\C=C(C)C
• Target: MAPK,p38 MAPK
• Solubility: DMSO:25 mg/mL (100.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.05 mM)

Bioactivity

• In Vitro:
  Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bisabolangelone, p38MAPK, p38 MAPK, inhibit, Inhibitor, IL Receptor, MAPK, TNF-α

Compound Identifiers

PubChem CID

10399769