BiP inducer X

SKU: orb1940349

Description

BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.(In Vitro):Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.(In Vivo):In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction.

Key Properties

• CAS Number: 101714-41-4
• MW: 209.22
• Purity: >98% (HPLC)
• Formula: C₉H₇NO₃S
• SMILES: Oc1ccc(cc1O)C(=O)CSC#N
• Target: Apoptosis
• Solubility: In Vitro: DMSO : 50 mg/mL (238.98 mM)

Bioactivity

• In Vivo:
  BiP inducer X administration reduces the insults due to cerebral infarction. A 20 μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. Animal model: Male adult ddY mice weighing 24-34 g (Japan SLC). Dosage: 20 μg (2 μl). Administration: Intracerebroventricularly. Result: Significantly increased the level of BiP protein 24 h after administration, confirming that administration of BIX induces BiP protein In vivo.
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• In Vitro:
  BiP inducer X (5 μM; 0-12 hours; SK-N-SH cells) increase BiP protein. The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway. BiP inducer X (5 μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIX

Quick Database Links

Gene Symbol

Apoptosis