BIP-135

SKU: orb1707549

Description

BIP-135 is a potent, ATP-competitive inhibitor selective for GSK-3α and GSK-3β, with IC50 values of 16 nM and 21 nM, respectively. It demonstrates neuroprotective properties and is a valuable research tool for studying glycogen synthase kinase-3 in both cellular and animal models of neurological function and disease.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 941575-71-9
• MW: 421.24
• Purity: 99.93% (May vary between batches)
• Formula: C₂₁H₁₃BrN₂O₃
• SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccccc23)c2cc(Br)ccc12
• Target: GSK-3
• Solubility: DMSO:56.7 mg/mL (134.6 mM)

Bioactivity

• Target IC50:
  GSK-3α:16 nM|GSK-3β:21 nM
• In Vivo:
  BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
• In Vitro:
  BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BIP 135, BIP135, BIP-135, GSK-3β, GSK-3α, GSK3

Compound Identifiers

PubChem CID

16741475