BIO-32546

SKU: orb1710253

Description

BIO-32546 (S-isomer) is a potent and selective autotaxin (ATX) inhibitor with a 1 nM IC50. This tool compound is widely used in vitro to study lysophosphatidic acid (LPA) signaling and has been utilized in vivo to investigate ATX's role in fibrosis, cancer, and inflammation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1548743-66-3
• MW: 543.54
• Purity: 98.03% (May vary between batches)
• Formula: C₂₈H₃₁F₆NO₃
• SMILES: C(F)(F)(F)C=1C2=C(C=CC1O[C@@H]3CC[C@H](C(F)(F)F)CC3)C=CC([C@H](C)N4C5(CC(C(O)=O)CC4(CC5)[H])[H])=C2
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.07 mM);DMSO:90 mg/mL (165.58 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autotaxin (ATX), ATX (autotaxin), BIO32546, BIO-32546, BIO 32546

Compound Identifiers

PubChem CID

90027494