Binodenoson

SKU: orb1298050

Description

Binodenoson (WRC-0470) is a selective A2A adenosine receptor agonist with a KD of 270 nM. It acts as a short-acting coronary vasodilator for pharmacological stress testing in myocardial perfusion imaging, facilitating research in cardiovascular disease models both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 144348-08-3
• MW: 391.42
• Purity: 99.84% (May vary between batches)
• Formula: C₁₇H₂₅N₇O₄
• SMILES: Nc1nc(N\N=C\C2CCCCC2)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
• Target: Adenosine Receptor
• Solubility: DMSO:11 mg/mL (28.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.11 mM)

Bioactivity

• Target IC50:
  A2A:270 nM(kd)
• In Vivo:
  Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage.
• In Vitro:
  2-(cyclohexylmethylidenehydrazino)adenos (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P1 receptor, oxidative, radiotracers, WRC0470, WRC-0470, WRC 0470, stress, Binodenoson, 2-(cyclohexylmethylidenehydrazino)adenos, AdenosineReceptor, Adenosine Receptor, A2A, Inhibitor, neutrophil, inhibit, MRE0470, MRE-0470, MRE 0470, imaging, myocardial

Compound Identifiers

PubChem CID

9576912