Bimiralisib

SKU: orb1305862

Description

Bimiralisib

Research Area

Signal Transduction

Key Properties

• CAS Number: 1225037-39-7
• MW: 411.38
• Purity: 99.88%
• Formula: C₁₇H₂₀F₃N₇O₂
• SMILES: Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
• Target: mTOR,PI3K,S6 Kinase
• Solubility: DMSO:5 mg/mL (12.15 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.43 mM)

Bioactivity

• Target IC50:
  DNA-PK:8567 nM|PI3Kα:1.5 nM(Kd)|PI3Kβ:11 nM(Kd)|PI3Kα (E542K):136 nM|PI3Kα (E542K):63 nM|PI3Kγ:25 nM(Kd)|mTOR:12 nM(Kd)|PI3Kα (H1047R):36 nM|VPS34:6486 nM|PI3Kδ:25 nM(Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bimiralisib, 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Mammalian target of Rapamycin, Inhibitor, mTOR, inhibit, S6 Kinase, S6Kinase, Phosphoinositide 3-kinase, pPKB, PQR309, PQR-309, PQR 309, pS6, PI3K, PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, PI3K-IN-2

Compound Identifiers

PubChem CID

58507717