BIM-46174 HCl

SKU: orb2308734

Description

BIM-46174 HCl is a selective G protein inhibitor that exhibits broad-spectrum anticancer activity by suppressing the proliferation of numerous human cancer cell lines and triggering caspase-3-dependent apoptosis. Its utility extends to in vitro studies of G protein signaling in oncology research and in vivo models investigating tumor growth inhibition.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 435.03
• Purity: 99.83% (May vary between batches)
• Formula: C₂₂H₃₁ClN₄OS
• SMILES: Cl.N[C@@H](CS)C(=O)N1CCn2cc(nc2[C@@H]1CC1CCCCC1)-c1ccccc1
• Target: GPCR,Apoptosis
• Solubility: DMSO:22.62 mg/mL (52 mM)

Bioactivity

• In Vitro:
  BIM-46174 HCl (195450-11-4 Free base) (3, 10, 30, 100 μM) inhibits the growth of a wide range of human cancer cell lines (e.g., HL60 and NCI-H69 cells), including anticancer drug-resistant cells; BIM-46174 HCl (195450-11-4 Free base) induces caspase-3-dependent apoptosis and poly (ADP-ribose) polymerase cleavage in these cancer cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, BIM-46174 HCl(195450-11-4 Free base), BIM46174HCl(195450114Freebase), GPR

Compound Identifiers

PubChem CID

172009707