BIIB021 mesylate

SKU: orb3173356

Description

BIIB021 (CNF2024) mesylate is the mesylate salt form of BIIB021. BIIB021 is an orally active Hsp90 inhibitor. It suppresses the proliferation of drug-resistant chronic myeloid leukemia (CML) cells, with IC50 values for K562, K562/G, 32Dp210, and 32Dp210-T315I cells recorded at 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 induces the degradation of BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. Furthermore, BIIB021 can induce autophagy in CML cells and is applicable for CML research.

Key Properties

• CAS Number: 1225041-97-3
• MW: 414.87
• Formula: C₁₅H₁₉ClN₆O₄S
• SMILES: O=S(=O)(O)C.ClC1=NC(=NC2=C1N=CN2CC3=NC=C(C(OC)=C3C)C)N
• Target: HSP,c-Myc,Autophagy,Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP,c-Myc,Autophagy,Wnt/beta-catenin