Bicyclol

SKU: orb1223406

Description

Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Bicyclol promotes toll-like 2 receptor recruiting inosine 5'-monophosphate dehydrogenase II to exert its anti-inflammatory effect.

Key Properties

• CAS Number: 118159-48-1
• MW: 390.34
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈O₉
• SMILES: COc1c2c(c(c(c1)CO)c1c3c(c(cc1C(=O)OC)OC)OCO3)OCO2
• Target: Histamine Receptor
• Solubility: DMSO : ≥ 68 mg/mL. 174.21 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bicyclol | SY 801 | SY-801 | SY801

Quick Database Links

Gene Symbol

Histamine Receptor