BIBS 39

SKU: orb1697215

Description

BIBS 39 is a selective, non-peptide antagonist of the angiotensin II receptor. It is utilized in cardiovascular and renal research to investigate the renin-angiotensin system in both in vitro binding assays and in vivo models of hypertension.

Research Area

Metabolism Research

Key Properties

• CAS Number: 133085-33-3
• MW: 524.65
• Purity: 99.69%
• Formula: C₃₂H₃₆N₄O₃
• SMILES: CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O
• Target: RAAS
• Solubility: 10% DMSO+90% Corn Oil:1.5 mg/mL (2.86 mM);DMSO:32 mg/mL (60.99 mM)

Bioactivity

• Target IC50:
  AT1 receptor:29 ± 7 nM (ki)|AT2 receptor:480 ± 110 nM (ki)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, AT2 receptor, Angiotensin Receptor, BIBS 39, BIBS39, BIBS-39

Compound Identifiers

PubChem CID

131590