Biatractylolide

SKU: orb1680280

Description

Biatractylolide is a bioactive natural compound utilized in life science research. It serves as a valuable tool for in vitro and in vivo studies, particularly in pharmacological and phytochemical investigations exploring its biological activities.

Research Area

Cell Biology

Key Properties

• CAS Number: 182426-37-5
• MW: 462.62
• Formula: C₃₀H₃₈O₄
• SMILES: CC1=C2[C@@](C[C@@]3(C)[C@](C2)(C(=C)CCC3)[H])(OC1=O)[C@]45C(C[C@]6([C@](C)(C4)CCCC6=C)[H])=C(C)C(=O)O5
• Target: Apoptosis,Others

Bioactivity

• In Vivo:
  In SD rats with hippocampal Aβ₁₋₄₂-induced Alzheimer's disease model, oral administration of Biatractylolide (20 and 40 mg/kg/day, for 14 days) improved cognitive function (shortened escape latency in the Morris water maze), and reduced expression of p-Tau and cleaved caspase-3 in hippocampal tissue, suggesting neuroprotective and anti-Alzheimer’s potential.
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• In Vitro:
  In PC12 cells, Biatractylolide significantly attenuated Aβ₁₋₄₂-induced cytotoxicity (20, 40, and 80 μM, 24 h), increased cell viability, reduced ROS levels, and suppressed apoptosis-related protein expression (e.g., cleaved caspase-3 and Bax/Bcl-2 ratio), indicating antioxidant and anti-apoptotic properties.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Biatractylolide, (+)-Biatractylolide

Compound Identifiers

PubChem CID

11225032