BIA 10-2474

SKU: orb1304289

Description

BIA 10-2474

Research Area

Cell Biology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 1233855-46-3
• MW: 300.36
• Purity: 99.27% (May vary between batches)
• Formula: C₁₆H₂₀N₄O₂
• SMILES: CN(C1CCCCC1)C(=O)n1cnc(c1)-c1ccc[n+]([O-])c1
• Target: Autophagy,FAAH
• Solubility: DMSO:4 mg/mL (13.32 mM)

Bioactivity

• Target IC50:
  FAAH (rat brain regions):50-70mg/kg (IC50)
• In Vivo:
  In January 2016, a Phase I clinical trial involving the drug BIA 10-2474 experienced severe adverse events (SAE), including a fatality. Investigations into the trial's failure will explore various potential causes, such as off-target effects, miscalculated dosage, unforeseen immune responses, interspecies variability, and cumulative dose toxicity.
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• In Vitro:
  ExVivo: BIA 10-2474 is a potent FAAH inhibitor with IC50 values of 52 mg/kg (cerebellum), 67 mg/kg (rest of brain), 68 mg/kg (cortex), and 71 mg/kg (hypothalamus), and 50-70 mg/kg (i.p.) in various brain regions .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, BIA 10 2474, BIA 102474, BIA 10-2474, BIA10-2474, inhibit, Inhibitor, Fatty acid amide hydrolase, FAAH

Compound Identifiers

PubChem CID

46831476