BI8626

SKU: orb1989446

Description

BI8626 is a small molecule inhibitor of the ubiquitin ligase HUWE1. It demonstrates protective effects in a spontaneous desiccation syndrome model using NOD/ShiLtj mice. In vitro, it reduces intracellular cholesterol, suppresses markers of T-cell activation like p-ZAP-70 and CD25, and inhibits CD4+ T-cell proliferation, making it a useful research tool for immunology and autoimmunity studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1875036-75-1
• MW: 440.54
• Purity: 99.84% (May vary between batches)
• Formula: C₂₅H₂₈N₈
• SMILES: NCc1cccc(CNc2ncnc3c(ncnc23)N2CCN(Cc3ccccc3)CC2)c1
• Target: E1/E2/E3 Enzyme
• Solubility: DMSO:60 mg/mL (136.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM)

Bioactivity

• Target IC50:
  HUWE1:0.9 μM
• In Vitro:
  In LS174T cells, BI8626 (0μM, 5μM, 10μM, 15μM, 20μM; 0-4 days) delayed progression through all phases of the cell cycle, with the most pronounced effect on the G1 phase.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E1Enzyme, E1 Enzyme, E3 Enzyme, E2 Enzyme, E2Enzyme, E3Enzyme, BI 8626, BI8626, BI-8626, HUWE1

Compound Identifiers

PubChem CID

138377589