BI8622

SKU: orb1707555

Description

BI8622 is a specific HUWE1 ubiquitin ligase antagonist that rescues mutant RP2 protein levels in retinal cells and suppresses NLRP3, NLRC4, and AIM2 inflammasome activation. This small molecule is a valuable research tool for studying inherited retinal diseases and inflammasome-related pathologies in cellular models.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 1875036-74-0
• MW: 426.51
• Purity: 98.28%
• Formula: C₂₅H₂₆N₆O
• SMILES: N#CC1(C=2C=CC=CC2)CCN(C=3N=CN=C(C(=O)NC4=CC=C(C=C4)CN)C3C)CC1
• Target: E1/E2/E3 Enzyme,DNA/RNA Synthesis,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138377590