BI-9321 trihydrochloride

SKU: orb2665612

Description

BI-9321 trihydrochloride is a potent and selective antagonist of the NSD3-PWWP1 domain. This compound suppresses Myc mRNA expression and inhibits cellular proliferation, as demonstrated in studies using MOLM-13 leukemia cells. It serves as a valuable chemical probe for investigating epigenetic targets in oncology research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2387510-87-2
• MW: 469.81
• Purity: 99.96% (May vary between batches)
• Formula: C₂₂H₂₄Cl₃FN₄
• SMILES: FC1=CC=C2C(N=CC=C2C3=C(C4=C(C)C=C(CN)C=C4C)N=CN3C)=C1.Cl.Cl.Cl
• Target: Histone Methyltransferase
• Solubility: DMSO:200 mg/mL(425.70 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.26 mM);H2O:20 mg/mL(42.57 mM)

Bioactivity

• Target IC50:
  U2OS cells:1.2 μM
• In Vitro:
  BI-9321 trihydrochloride specifically interfered with the interaction between the NSD3-PWWP1 structural domain and histones, with an IC50=1.2 μM in U2OS cells. BI-9321 trihydrochloride targeted the methyl lysine binding site of the PWWP1 structural domain and effectively bound its intracellular target at 1 µM concentration. In addition, BI-9321 trihydrochloride significantly down-regulated the expression of Myc mRNA and reduced the proliferation of MOLM-13 cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSD3-PWWP1, HistoneMethyltransferase, Histone Methyltransferase, BI9321, BI-9321, BI9321 3HCl, BI9321 trihydrochloride, BI-9321 Trihydrochloride, BI 9321

Compound Identifiers

PubChem CID

145874876