BI-8128

SKU: orb3210336

Description

BI-8128 is a potent EGFR inhibitor with IC50 values of 12, 6.7, 22, 10, and 3 nM for wild-type EGFR and the T790M, C797S, T790M/C797S, and L858R/T790M/C797S mutant forms, respectively. It significantly inhibits the proliferation of Ba/F3 and PC-9 cells with resistant mutations. BI-8128 is applicable for research in non-small cell lung cancer.

Key Properties

• CAS Number: 2769714-36-3
• MW: 610.71
• Formula: C₃₂H₃₈N₁₀O₃
• SMILES: CN1C=2C(=C(N=C(C2)N3C=4C(C=N3)=C(C)N=C(C4)C=5C(OC)=CC=NC5)N6[C@@]7(C[C@](C6)(OC7)[H])[H])N=C1N8CCN(CCOC)CC8
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR