BI-78D3

SKU: orb1300469

Description

BI-78D3 is a potent and selective competitive inhibitor of JNK with an IC50 of 280 nM. It exhibits over 100-fold selectivity against p38α and shows no activity toward mTOR or PI3K. This compound is a valuable research tool for studying JNK signaling in cellular models of inflammation, apoptosis, and metabolic disease.

Research Area

Signal Transduction

Key Properties

• CAS Number: 883065-90-5
• MW: 379.37
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₉N₅O₅S₂
• SMILES: [O-][N+](=O)c1cnc(Sc2n[nH]c(=O)n2-c2ccc3OCCOc3c2)s1
• Target: JNK
• Solubility: Ethanol:1.9 mg/mL (5.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM);DMSO:37.9 mg/mL (99.9 mM)

Bioactivity

• Target IC50:
  JNK:280 nM
• In Vivo:
  In animal studies, BI-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes.
• In Vitro:
  BI-78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding and prevents JNK substrate phosphorylation.
• Cell Research:
  Cells are subjected to a dose range of doxorubicin concentrations in the presence or absence of a non-toxic dose (10 nM) of the small molecule JIP1-inhibitor BI-78D3. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, JNK, Inhibitor, BI78D3, BI-78D3, BI-78D-3, BI 78D3

Compound Identifiers

PubChem CID

2747117