BI-671800

SKU: orb1308569

Description

BI-671800 is a potent and selective antagonist of the CRTH2 (DP2) receptor, with IC50 values of 4.5 nM (human) and 3.7 nM (mouse) for inhibiting PGD2 binding. This investigational compound is used in research to study allergic asthma mechanisms, supporting both in vitro binding assays and in vivo models of airway inflammation.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1093108-50-9
• MW: 501.5
• Purity: 99.19% (May vary between batches)
• Formula: C₂₅H₂₆F₃N₅O₃
• SMILES: CN(C)c1nc(Cc2ccc(NC(=O)c3ccc(cc3)C(F)(F)F)cc2)nc(N(C)C)c1CC(O)=O
• Target: GPCR,Prostaglandin Receptor
• Solubility: DMSO:130 mg/mL (259.22 mM)

Bioactivity

• Target IC50:
  CRTH2 (human):4.5 nM (in CRTH2 transfected cells)|CRTH2 (mouse):3.7 nM (in CRTH2 transfected cells)
• In Vivo:
  BI-671800 (compound A, 0.1-10 mg/kg, i.g.) significantly inhibits AHR in mice and effectively prevents edema formation, reduces inflammatory infiltrate, and alleviates skin pathology observed in drug vehicle-treated animals.
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• In Vitro:
  BI-671800 (compound A) is a potent small-molecule antagonist with low nanomolar potency against human or mouse CRTH2 in transfected cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP 761, AP761, AP-761, BI 671800, BI671800, BI-671800, Cmpd A, CRTh2 (DP2) receptor, inhibit, mCRTH2, hCRTH2, Inhibitor, ProstaglandinReceptor, Prostaglandin Receptor

Compound Identifiers

PubChem CID

45270144