BI-4732

SKU: orb2308700

Description

BI-4732 is a brain-penetrant EGFR tyrosine kinase inhibitor effective against T790M mutations. It is used in preclinical research for studying EGFR-driven cancers, demonstrating antitumor activity in both in vitro assays and in vivo models of non-small cell lung cancer and brain metastases.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2769715-68-4
• MW: 592.69
• Purity: 98.88% (May vary between batches)
• Formula: C₃₂H₃₆N₁₀O₂
• SMILES: CN1C=2C(=C(N=C(C2)N3C=4C(C=N3)=C(C)N=C(C4)C=5C(OC)=CC=NC5)N6[C@@]7(C[C@](C6)(OC7)[H])[H])N=C1N8C[C@@]9(N(CC8)CCC9)[H]
• Target: ERK,S6 Kinase,Akt,EGFR
• Solubility: DMSO:4 mg/mL (6.75 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BI4732, EGFR

Compound Identifiers

PubChem CID

164514234