BI-3802

SKU: orb1225654

Description

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells); BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.

Key Properties

• CAS Number: 2166387-65-9
• MW: 484.985
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₉ClN₆O₃
• SMILES: O=C(NC)COC1=CC2=C(N(C)C1=O)C=CC(NC3=NC(N4C[C@@H](C)C[C@@H](C)C4)=NC=C3Cl)=C2
• Target: Bcl-2
• Solubility: DMSO : 5 mg/mL 10.31 mM; Methanol : 2 mg/mL 4.12 mM; H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BI3802 | BI 3802

Quick Database Links

Gene Symbol

Bcl-2