BI-2493

SKU: orb1737459

Description

BI-2493 is a structural analog of BI-2865 and functions as a potent, highly selective pan-KRAS inhibitor. It demonstrates antitumor efficacy by inhibiting tumor cell growth in vitro and has shown activity in in vivo models, supporting its use in cancer research.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2937344-16-4
• MW: 461.58
• Purity: 99.88% (May vary between batches)
• Formula: C₂₄H₂₇N₇OS
• SMILES: C(#N)C=1C=2[C@@]3(C4=C(C(=NO4)C5=NC(=NC=C5)N6[C@@H](C)CNCC6)CCC3)CCCC2SC1N
• Target: Kras,Ras
• Solubility: DMSO:60 mg/mL (129.99 mM)

Bioactivity

• Target IC50:
  SNU-245 cells:136.1 nM|KRAS (G12D):2 nM|KRAS (G12V):11 nM|SAS cells:413.4 nM|HuG1-N cells:59.1 nM|KRas (G12C):3 nM|HSKTC cells:130.0 nM
• In Vivo:
  METHODS: A cell line-derived xenograft model was established, and mice were randomly assigned according to tumor size (n = 7-8 mice per treatment group) and treated with BI-2493 (10-90 mg/kg, orally twice daily) . RESULTS BI-2493 attenuated tumor growth in xenograft model mice.
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• In Vitro:
  METHODS: ASPC1, HPAC and H727 cells were treated with BI-2493 (Log (1-4nM)), and cell viability was detected after 72 hours. RESULTS BI-2493 inhibited the growth of ASPC1, HPAC and H727 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BI2493, BI-2493, BI 2493, KRAS

Compound Identifiers

PubChem CID

168268198