BI-187004

SKU: orb1297995

Description

BI-187004 is a potent and selective small molecule inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). It is used in research to investigate the enzyme's role in metabolic diseases, such as type 2 diabetes and obesity, in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1303515-32-3
• MW: 342.39
• Purity: 98.63% (May vary between batches)
• Formula: C₂₁H₁₈N₄O
• SMILES: C(=O)(N1[C@@]2([C@@](C=3C(C2)=CC=C(C#N)C3)(CCC1)[H])[H])C=4C=C5C(=CC4)N=CN5
• Target: Dehydrogenase
• Solubility: DMSO:50 mg/mL (146.03 mM)

Bioactivity

• In Vivo:
  BI-187004 was administered once daily for 14 days to eight patients with type 2 diabetes mellitus. N-methylation was identified as a major biotransformation pathway.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

11-beta-hydroxysteroid dehydrogenase, BI 187004, BI187004, BI-187004

Compound Identifiers

PubChem CID

67223373