BI-1408

SKU: orb1710264

Description

BI-1408 is a potent γ-secretase modulator, exhibiting an IC50 of 0.04 μM against Aβ42 production. This small molecule inhibitor is a valuable research tool for in vitro and in vivo studies investigating Alzheimer's disease pathology and Notch signaling pathways.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2231075-94-6
• MW: 390.46
• Purity: 99.63% (May vary between batches)
• Formula: C₂₂H₂₃FN₆
• SMILES: N(C=1N=C2C(=CC=CN2N1)C3=C(C)C=C(F)C=C3)[C@H]4CC5=C(CC4)N(CC)N=C5
• Target: Gamma-secretase,Beta Amyloid
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  β-Amyloid (1-42):40 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-secretase, Aβ42, BI 1408, BI1408, BI-1408, Gammasecretase

Compound Identifiers

PubChem CID

138319684