BI-1347

SKU: orb1301817

Description

BI-1347 is a highly potent and selective CDK8/cyclin C kinase inhibitor with an IC50 of 1 nM. It has demonstrated efficacy in suppressing tumor growth in xenograft models, supporting its use in oncology research for studying transcriptional regulation and cancer cell proliferation in both cellular and animal studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 2163056-91-3
• MW: 356.42
• Purity: 99.63%
• Formula: C₂₂H₂₀N₄O
• SMILES: CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12
• Target: CDK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.22 mM);DMSO:120 mg/mL (336.68 mM)

Bioactivity

• Target IC50:
  CDK8:1 nM (cell free)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclin dependent kinase, CDK8, CDK, BI 1347, BI1347, BI-1347, anti-tumoral activity, inhibit, mouse splenic NK cell, oral activity, Inhibitor, human NK92MI cell, selectivity

Compound Identifiers

PubChem CID

132180482