BI-0252

SKU: orb1707565

Description

BI-0252 is a potent and selective MDM2-p53 interaction inhibitor with an IC50 of 4 nM. It demonstrates robust in vivo efficacy, inducing complete tumor regression in SJSA-1 xenograft models, which is associated with activation of p53 target genes and apoptotic markers. This molecule is a valuable chemical probe for researching p53 pathway biology in cancer models both in vitro and in vivo.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1818291-27-8
• MW: 566.45
• Formula: C₃₀H₂₆Cl₂FN₃O₃
• SMILES: C(N1[C@@]2([C@H]([C@]3([C@@]1(C[C@@H](N3)C4=CC=C(C(O)=O)C=C4)[H])[H])C5=C(F)C(Cl)=CC=C5)C=6C(NC2=O)=CC(Cl)=CC6)C7CC7
• Target: E1/E2/E3 Enzyme,Others,MDM-2/p53

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118439587