Bfl-1-IN-5

SKU: orb2695510

Description

Bfl-1-IN-5 ((R,R,S)-26) is a potent and selective Bfl-1 inhibitor (IC50 = 22 nM). It induces caspase-3/7 activity (EC50 = 370 nM) and reduces viability in SU-DHL-1 lymphoma cells (EC50 = 1.3 µM), making it a useful chemical probe for studying Bcl-2 family protein function and apoptosis mechanisms in cancer research.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• MW: 443.46
• Formula: C₂₄H₂₄F₃N₃O₂
• SMILES: C(CNC(C)=O)[C@H]1C=2C3=C(C=CC2CC1)N=C(C)O3
• Target: Bcl-2 Family,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

57781216