Betulinic acid

SKU: orb1304966

Description

Betulinic acid

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 472-15-1
• MW: 456.70
• Purity: 98.22%
• Formula: C₃₀H₄₈O₃
• SMILES: C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@H](O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]
• Target: Parasite,Endogenous Metabolite,NF-κB,Apoptosis,Mitophagy,HIV Protease,Autophagy,Topoisomerase,Aminopeptidase
• Solubility: 10% DMSO+90% Corn Oil:1.50 mg/mL (3.28 mM);DMSO:33.30 mg/mL (72.91 mM);Ethanol:10.00 mg/mL (21.90 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Aminopeptidase N:7.3 μM|Topo I (eukaryotic):5 μM|HIV-1:1.4 μM(EC50)
• In Vivo:
  As an anti-melanoma agent, Betulinic acid inhibit the activity of aminopeptidase N IC50 7.3 μM). It exhibits anti-HIV properties by blocking HIV replication in H9 lymphocytes (EC50: 1.4 μM) and inhibitin the growth of uninfected H9 cells IC50 13 μM). Moreover, Betulinic acid shows potential as an anti-cancer andidate, suppressin the activity of eukaryotic topoisomerase I IC50 5 μM).
• In Vitro:
  In LNCaP cell cultures of athymic nude mice, Betulinic acid inhibit the growth of prostate cancer cells and tumors (xenografts). This inhibitory effect is partly due to the downregulation of protease-dependent Sp1/3/4 and several SP-regulated genes.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Topoisomerase, NF-kB, NFkB, NFκB, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, Mitochondrial Autophagy, Mitophagy, Lupatic acid, inhibit, Endogenous Metabolite, EndogenousMetabolite, Eukaryotic topoisomerase I, Inhibitor, Human immunodeficiency virus, HIVProtease, HIV-1, HIV Protease, HIV, Betulic acid, Betulinic acid, Apoptosis, Autophagy, ALS357, ALS-357, ALS 357, Aminopeptidase N

Compound Identifiers

PubChem CID

64971