Beta-Hydroxyisovalerylshikonin

SKU: orb1297444

Description

Beta-Hydroxyisovalerylshikonin

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 7415-78-3
• MW: 388.41
• Purity: 99.59%
• Formula: C₂₁H₂₄O₇
• SMILES: CC(C)=CC[C@@H](OC(=O)CC(C)(C)O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Target: Tyrosine Kinases,Src,EGFR,Fatty Acid Synthase,Prostaglandin Receptor,AMPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.57 mM);DMSO:10 mg/mL (25.75 mM)

Bioactivity

• Target IC50:
  Viability:30.9 μg/ml|EGFR:0.7 microM|v-Src:1 microM
• In Vitro:
  By using different chromatographic techniques and appropriate spectroscopic methods the seven naphthoquinones were described: deoxyshikonin ( 1 ), isobutyrylshikonin ( 2 ), ± methylbutyrylshikonin ( 3 ), acetylshikonin ( 4 ), Beta-Hydroxyisovalerylshikonin( 5 ), 5,8-O-dimethyl isobutyrylshikonin ( 6 ) and 5,8-O-dimethyl deoxyshikonin ( 7 ). Amon the tested compounds, 3 and 4 exhibite the highest antibacterial activities toward All tested bacterial species ( IC50 and MIC90 for gram positive bacteria: 6.40 μg/ml-12.79 μg mL and 6.82 μg/ml-13.60 μg/ml, respectively for gram negative bacteria: 4.27 μg/ml-8.53 μg mL and 4.77 μg/ml-9.54 μg/ml, respectively. Also, naphthoquinones 3 and 4 exhibited strong cytotoxic activity against MDA-MB-231 cells IC50 Values 86.0 μg mL and 80.2 μg/ml, respectively , while compounds 1 , 3 , 4 and 5 significantly decreased viability of HCT116 cells IC50 Values of 97.8 μg/ml, 15.2 μg/ml, 24.6 μg mL and 30.9 μg/ml, respectively

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

PGE, Src, PTK, Prostaglandin Receptor, ProstaglandinReceptor, β-Hydroxyisovalerylshikonin, Tyrosine Kinases, TyrosineKinases, b-Hydroxyisovalerylshikonin, AMPK, BetaHydroxyisovalerylshikonin, Beta-Hydroxyisovalerylshikonin, Beta Hydroxyisovalerylshikonin, HER1, Epidermal growth factor receptor, EGFR, ErbB-1, Fatty Acid Synthase, Fatty Acid Synthase (FASN), FattyAcidSynthase, inhibit, Inhibitor

Compound Identifiers

PubChem CID

479502