beta-Amyrone

SKU: orb1297121

Description

β-Amyrone is a bioactive small molecule with antiviral activity against Chikungunya virus (EC50 = 86 µM), anti-inflammatory effects via COX-2 suppression, and inhibitory activity against α-glucosidase and AChE. It is a useful research tool for studying viral infections, inflammatory processes, and metabolic disorders like obesity.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Neuroscience

Key Properties

• CAS Number: 638-97-1
• MW: 424.7
• Purity: 99.55% (May vary between batches)
• Formula: C₃₀H₄₈O
• SMILES: CC1(C)CCC2(C)CCC3(C)C(=CCC4C5(C)CCC(=O)C(C)(C)C5CCC34C)C2C1
• Target: Antifection|||COX|||AChR|||PPAR
• Solubility: Ethanol:< 0.1 mg/ml (insoluble);DMSO:4.25 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  In ear phenol-induced edema in Balb C mice, beta-Amyrone (0.1, 0.3, 0.6 mg/kg) inhibits ear edema formation in a dose-related manner.
• In Vitro:
  beta-Amyrone inhibits α-glucosidase AChE and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively. In LPS-stimulated J774 cells, beta-Amyrone (2.5, 5, 10 μg/mL) inhibits NO production with an IC50 value of 4.61 μg/mL without obvious effects on cell viability. beta-Amyrone (10 μg/mL) inhibits IL-6, IL-10 levels, and COX-2 expression at the dose of 10 μg/mL.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX-2, COX, Cyclooxygenase, beta-Amyron, beta-Amyrone, CHIKV, AChE, AChR, b-Amyron, b-Amyrone, Anti-inflammatory, Antifection, antifungal, Fungal, Inhibitor, obesity, infection, inflammation, inhibit, β-Amyrone, β-Amyron, Peroxisome proliferator-activated receptors, PPAR, PI3K-Akt

Compound Identifiers

PubChem CID

612782