beta-Amyrin acetate

SKU: orb1297446

Description

beta-Amyrin acetate is a dual inhibitor of HMG-CoA reductase (IC50 = 3.4 µM) and soluble epoxide hydrolase (sEH). This compound exhibits anti-hyperlipidemic, anti-inflammatory, antioxidant, and antifungal properties, supporting its investigation in metabolic and inflammatory disease research using in vitro assays.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1616-93-9
• MW: 468.75
• Purity: 99.87% (May vary between batches)
• Formula: C₃₂H₅₂O₂
• SMILES: [H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](OC(C)=O)C(C)(C)[C@]3([H])CC[C@@]12C
• Target: Antifungal,Antioxidant,Epoxide Hydrolase,HMG-CoA Reductase
• Solubility: DMSO:< 1 mg/mL (insoluble);Ethanol:< 1 mg/mL (insoluble);H2O:< 1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  In Xylene-induced mouse ear topical edema model, beta-Amyrin acetate (100 μg/ear) significantly inhibits xylene-induced ear edema. In normal and arthritic rats, beta-Amyrin acetate (40 mg/kg; s.c.) increases the ATP-phosphohydrolase activity in liver homogenates. In adult albino rats, beta-Amyrin acetate (40 mg/kg; i.p.) shows significant anti-inflammatory activities to 43.6% with mean average weight of granulation tissue of 9.2 mg after 6 days.
• In Vitro:
  beta-Amyrin acetate (25 μM) decreases mEH activity to 61% of control activity. beta-Amyrin acetate (50 μg/mL) inhibits heat-induced hemolysis and hypotonicity-induced hemolysis of human erythrocytes. beta-Amyrin acetate (7.8-1000 μg/mL) inhibits all of the Candida fungal species tested (MIC: 30 - 250 μg/mL).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

sEH, β-Amyrin, β-Amyrin Acetate, inflammation, Immunology & Inflammation related, inhibit, LDL, HMGCoAReductase, HMGCoA Reductase, HMG-CoA, HMG-CoA Reductase (HMGCR), Inhibitor, hemolysis, Epoxide Hydrolase, EpoxideHydrolase, Fungal, beta Amyrin acetate, betaAmyrin acetate, beta-Amyrin Acetate, b-Amyrin Acetate, arthritic, antifungal, Antifungal, Antioxidant, anti-inflammatory

Compound Identifiers

PubChem CID

92156