Bestatin HCl

SKU: orb1304117

Description

Bestatin hydrochloride

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 65391-42-6
• MW: 344.84
• Purity: >98%
• Formula: C₁₆H₂₄N₂O₄ · HCl
• SMILES: Cl.CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
• Target: Protease
• Solubility: Soluble in Water (up to 10 mg/ml). Also soluble in DMSO and Ethanol.

Bioactivity

• In Vivo:
  Bestatin is an active anti-angiogenic agent that may inhibit tumor angiogenesis in vivo and tube-like formation of endothelial cells in vitro through its inhibition of APN/CD13 activity. Oral administration of Bestatin (100-200 mg/kg/day) is found to significantly inhibit the melanoma cell-induced angiogenesis in a mouse dorsal air sac assay.
• In Vitro:
  Bestatin, also known as Ubenimex (INN), is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia. Bestatin can be administered, with low toxicity, to cultured cells, intact animals and humans. It has become a useful tool in elucidating the physiological role of some mammalian exopeptidases in the regulation of the immune system, in the growth of tumors and their invasion of surrounding tissues, and in the degradation of cellular proteins.
• Cell Research:
  Growing cells (1×106 to 2×106 cells/mL) are diluted to 1.0×103 cells/mL and transferred (3 mL) into a well in a 12-well multiwell plate (2.5-cm diameter/well). Cells are treated with 0, 10, 50, 100, 300, or 600 μM Bestatin and allowed to grow at 21°C shaking at 180 rpm for 48 h. A hemocytometer is used to measure cell density after 0, 24, and 48 h.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bestatin hydrochloride, Bestatin, Bestatin Hydrochloride, CD13, Antibiotic, Aminopeptidase, Bacterial, Inhibitor, inhibit, Ubenimex, Ubenimex hydrochloride, Ubenimex Hydrochloride

Compound Identifiers

PubChem CID

11957481