Bergaptol

SKU: orb1222192

Description

Bergaptol shows very good radical scavenging activity. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.

Key Properties

• CAS Number: 486-60-2
• MW: 202.16
• Purity: >98% (HPLC)
• Formula: C₁₁H₆O₄
• SMILES: C1=CC(=O)OC2=CC3=C(C=CO3)C(=C21)O
• Target: Others
• Solubility: DMSO : ≥ 50 mg/mL 247.33 mM; H2O : < 0.1 mg/mL

Bioactivity

• In Vivo:
  Animal model: LPS (40 μg/kg, i. c. v.)-treated mice. Dosage: 10-40 mg/kg. Administration: i.p. , once a day for two week. Result: Reduced LPS-induced fixation and cleavage of neuronal nuclei in the CA1 region of the hippocampus (H&E staining). Increasead the dendritic spine density of mice. Inhibited LPS-induced neuroinflammation.
• In Vitro:
  Western blot analysis. Cell line: LPS-induced RAW264.7 cells Concentration: 50 μg/mL. Incubation time: 24 h. Result: Inhibited JNK phosphorylation and NF-κB activation. Inhibited NF-κB P65 translocation from the cytosol to nucleus.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-Hydroxypsoralen | 4-Hydroxybergapten

Quick Database Links

Gene Symbol

Others