Berberine ursodeoxycholate

SKU: orb1745203

Description

Berberine ursodeoxycholate (HTD1801) is an ionic salt combining berberine and ursodeoxycholic acid, developed as an oral hypolipidemic agent. It demonstrates broad metabolic activity, including reducing hepatic fat, and is utilized in research models for hyperlipidemia, non-alcoholic steatohepatitis (NASH), and diabetes.

Key Properties

• CAS Number: 1868138-66-2
• MW: 727.93
• Purity: 97.39% (May vary between batches)
• Formula: C₄₄H₅₇NO₈
• SMILES: COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC([O-])=O
• Target: Others
• Solubility: DMSO:50 mg/mL (68.69 mM)

Bioactivity

• In Vivo:
  Berberine ursodeoxycholate (BUDCA) tested in this phase 2 study (1000 mg twice a day) results in a significant reduction in liver fat content after 18 weeks of treatment. This improvement in liver fat content is associated with improvement in glycemic control, the apparent improvement in hepatic inflammation and injury with reductions in serum levels of liver associated enzymes, significant weight loss, and modest reductions in serum lipid levels.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Berberine ursodeoxycholate, BUDCA, HTD 1801, HTD1801, HTD-1801

Compound Identifiers

PubChem CID

137552085