Berberine sulfate

SKU: orb1710699

Description

Berberine sulfate is a quaternary ammonium salt derived from protoberberine alkaloids. It is widely used in research on metabolic disorders, including type 2 diabetes, obesity, and fatty liver disease, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 316-41-6
• MW: 768.78
• Purity: 99.48% (May vary between batches)
• Formula: C₄₀H₃₆N₂O₁₂S
• SMILES: [O-]S([O-])(=O)=O.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
• Target: Others
• Solubility: H2O:38.46 mg/mL (50.03 mM);DMSO:7.69 mg/mL (10 mM)

Bioactivity

• In Vivo:
  Berberine sulfate (10, 30, or 50 mg/kg/day; gastrointestinal gavage; 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine (30 and 50 mg/kg/d; gastrointestinal gavage) inhibited the growth of human colorectal adenocarcinoma xenografts in nude mice by 33.1% and 45.3%, respectively.
  Read more...
• In Vitro:
  Berberine sulfate (1.25-160 μM; 72 h) has a potential inhibitory effect on the proliferation of four colorectal cancer cell lines, LoVo, HCT116, SW480, and HT-29. Berberine suLfate (1.25-160 μM; 24-72 h) induces time- and dose-dependent inhibition of LoVo cell growth. LoVo cells were exposed to Berberine sulfate (10 -80 μM) for 24 hours. Cell cycle analysis of LoVo cells treated with 40 μM berberine by flow cytometry showed an accumulation of cells in the G2/M phase. Berberine sulfate (10 -80 μM) inhibits the expression of cyclin B1, cdc2, and cdc25c proteins after 24 hours, especially at the dose of 80.0 μM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Berberal, Berberin sulfate, Berberin Sulfate, Berberine Sulfate, Berberine sulphate, AI3-61947

Compound Identifiers

PubChem CID

9424