Bepridil hydrochloride

SKU: orb1301830

Description

Bepridil hydrochloride

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 68099-86-5
• MW: 403
• Purity: 99.71%
• Formula: C₂₄H₃₅ClN₂O
• SMILES: Cl.CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
• Target: Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.93 mM);DMSO:130 mg/mL (322.58 mM)

Bioactivity

• In Vivo:
  The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered .
• In Vitro:
  Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium Channel, Ca channels, Ca2+ channels, CalciumChannel, CERM-1978, CERM 1978, CERM1978, Bepridil, Bepridil hydrochloride, Bepridil Hydrochloride, Inhibitor, inhibit

Compound Identifiers

PubChem CID

50088