Benzydamine hydrochloride

SKU: orb1310345

Description

Benzydamine hydrochloride (AF864) is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with additional local anesthetic and analgesic effects. It is utilized in research for studying inflammatory pathways and pain mechanisms in both in vitro cellular assays and in vivo animal models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 132-69-4
• MW: 345.87
• Purity: 99.01% (May vary between batches)
• Formula: C₁₉H₂₃N₃O·HCl
• SMILES: Cl.CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12
• Target: TNF,Antibacterial,PGE Synthase,COX
• Solubility: Ethanol:64 mg/mL (185.04 mM);DMSO:45 mg/mL (130.11 mM);H2O:63 mg/mL (182.15 mM)

Bioactivity

• In Vivo:
  Benzydamine significantly lower the incidence of postoperative sore throat (POST). At 6 hours after extubation, the incidence of POST is 17.0%. Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, AF864, AF-864, AF 864, Bacterial, COX, Benzydamine, Benzydamine HCl, Benzydamine hydrochloride, Benzydamine Hydrochloride, Prostaglandin E synthase, PGESynthase, PGE synthase, PGE Synthase

Compound Identifiers

PubChem CID

65464