Benztropine mesylate

SKU: orb1226545

Description

Benzatropine is an anticholinergic drug used in patients to reduce the side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, but not rigidity and bradykinesia. (In Vitro):Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne.Benztropine mesylate inhibits functions of cancer stem cells (CSCs) via the acetylcholine receptors, dopamine transporters/receptors, and/or histamine receptors.Benztropine mesylate induces the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination.(In Vivo):Benztropine mesylate (1.5 mg/kg; daily; for 3 weeks; Balb/c mice) treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model.

Key Properties

• CAS Number: 132-17-2
• MW: 403.53
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₅NO·CH₄SO₃
• SMILES: CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O
• Target: Dopamine Receptor
• Solubility: Ethanol: 81 mg/mL (200.72 mM); Water: 81 mg/mL (200.72 mM); DMSO: 50 mg/mL (123.9 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: MDA-MB-231 cells. Concentration: 0.1 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation time: 72 hours. Result: Inhibited the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. Cell Proliferation Assay Cell line: MDA-MB-231 cells. Concentration: 0, 1, 2, 5 μM. Incubation time: 4-6 days. Result: Suppressed mammosphere formation and self-renewal capacities of BCSCs in a dose-dependent manner in vitro.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 169913

Quick Database Links

Gene Symbol

Dopamine Receptor