Benzotript

SKU: orb1219922

Description

Benzotript is an gastrin-receptor antagonist, with anti-gastrinic.proglumide and benzotript, a new tryptophan derivative, to inhibit acid output from isolated gastric fundic parietal cells from rabbit. As measured with the [14C]aminopyrine (AP) accumulation method as an index of acid secretion, the two drugs inhibited basal AP with IC-50 values of 1 X 10(-2) M for proglumide and 1 X 10(-3) M for benzotript. In the case of secretagogue stimulation (1) benzotript slightly affected histamine-induced AP (15% inhibition at 5 X 10(-3) M), proglumide did not; (2) both proglumide and benzotript inhibited in a non-competitive manner acetylcholine-induced AP; (3) these isolated cells were sensitive to gastrin and the dose-response curve for the stimulant was biphasic (maximum for 1 X 10(-9) M), suggesting a desensitization mechanism. Proglumide and benzotript competitively inhibited both [125I]gastrin binding to its receptor sites and gastrin-induced AP, suggesting they are members of a class of gastrin-receptor antagonists.

Key Properties

• CAS Number: 39544-74-6
• MW: 342.78
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₅ClN₂O₃
• SMILES: O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C3=CC=C(Cl)C=C3)=O
• Target: gastrin-receptor

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

gastrin-receptor