Bengenin

SKU: orb1224989

Description

Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. (In Vitro):Bergenin (7.5-30μM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50=15 μM).Bergenin (7.5-30 μM; 24 hours) induces apoptosis in HeLa cervical cancer cells.(In Vivo):Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice.

Key Properties

• CAS Number: 477-90-7
• MW: 328.27
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆O₉
• SMILES: COC1=C(C=C2C(=C1O)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)OC2=O)O
• Target: IL Receptor
• Solubility: DMSO: 66 mg/mL (201.05 mM)

Bioactivity

• In Vivo:
  Pretreatment with Bergenin (12.5-100 mg/kg; i.p.; once) produces a dose-related inhibition of acetic acid-induced writhing in mice. Animal model: Male Swiss Webster C57BL/6 mice. Dosage: 12.5, 25, 50, 100 mg/kg. Administration: i.p.; Once. Result: Produced a dose-related inhibition of acetic acid-induced writhing in mice.
• In Vitro:
  Bergenin (7.5-30 μM; 24 hours) decreases the viability of HeLa cervical cancer cells (IC50 = 15 μM). Bergenin (7.5-30 μM; 24 hours) induces apoptosis in HeLa cervical cancer cells. Cell Viability Assay Cell line: HeLa cervical cancer cells. Concentration: 7.5, 15, 30 μM Incubation time: 24 hours. Result: Decreased the viability of HeLa cervical cancer cells. Cell Viability Assay Cell line: HeLa cervical cancer cells. Concentration: 7.5, 15, 30 μM Incubation time: 24 hours. Result: Induced apoptosis in HeLa cervical cancer cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(–)-Bergenin | Cuscutin | NSC 661749

Quick Database Links

Gene Symbol

IL Receptor