Benazepril hydrochloride

SKU: orb1310864

Description

Benazepril hydrochloride is an ACE inhibitor used in hypertension research. It is applied in both in vivo and in vitro studies to investigate cardiovascular mechanisms and is associated with a low incidence of transient liver enzyme elevations.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 86541-74-4
• MW: 460.95
• Purity: 99.89%
• Formula: C₂₄H₂₉ClN₂O₅
• SMILES: Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@H]1CCc2ccccc2N(CC(O)=O)C1=O
• Target: Apoptosis,RAAS,Angiotensin-converting Enzyme (ACE),ROS,Akt
• Solubility: H2O:23.1 mg/mL (50.11 mM);DMSO:45 mg/mL (97.62 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.34 mM)

Bioactivity

• In Vivo:
  Benazepril hydrochloride (3 or 10 mg/kg/d, p.o. for 14 days) dose-dependently inhibits the increase in the blood pressure caused by continuous norepinephrine (NE) infusion in spontaneously hypertensive rats (SHR) and suppresses in seizures induced by a monoamine oxidase inhibitor, tranylcypromine in NE infused SHR. Benazepril hydrochloride (30 mg/kg p.o.) decreases the triglyceride and total cholesterol levels in normotensive rats. Benazepril hydrochloride (3 mg/kg s.c.) causes a significant decrease in aortic atherosclerosis without reducing hypercholesterolemia in cholesterol-fed rabbits. Benazepril hydrochloride (100 mg/kg p.o.) shows no effect on the urine volume and urinary excretion of electrolytes but decreases PSP excretion in normotensive rats. Benazepril hydrochloride (10 mg/kg p.o.) inhibits the increase in the excretion of urinary protein in DOCA/salt spontaneously hypertensive rats. Benazepril Hydrochloride administration corrects systemic hypertension and significantly reduces angiotensin II and aldosterone in cats with experimentally induced or spontaneously occurring chronic renal failure. Benazepril hydrochloride administration reduces serum creatinine and urinary protein concentration in cat with experimentally induced or spontaneously occurring chronic renal failure. Benazepril hydrochloride significantly decreases blood pressure, angiotensin II and aldosterone and, increases upon discontinuation of administration to the pre-administration levels in a canine remnant kidney model of chronic renal failure.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACE, CGS 14824A HCl, Benazepril HCl, Benazepril

Compound Identifiers

PubChem CID

5362123