Bemnifosbuvir hemisulfate

SKU: orb1218400

Description

Bemnifosbuvir hemisulfate is a potent inhibitor of HCV virus replication.

Key Properties

• CAS Number: 2241337-84-6
• MW: 1261.15
• Purity: >98% (HPLC)
• Formula: C₄₈H₆₈F₂N₁₄O₁₈P₂S
• SMILES: C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O
• Target: SARS-CoV-2
• Solubility: DMSO : 170 mg/mL (269.60mM; Need ultrasonic)

Bioactivity

• In Vivo:
  When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver In vivo.
• In Vitro:
  Bemnifosbuvir hemisulfate has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively. In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AT-527

Quick Database Links

Gene Symbol

SARS-CoV-2